Professor Motti Deutsch
Professor Motti Deutsch
Director
Biography
Prof. Mordechai Deutsch is an Associate Professor in the Physics Department at Bar-Ilan University, where he received his PhD in Physics in 1991. Â He serves as Director of the Biophysical Interdisciplinary Jerome Schottenstein Center (JSC) for the Research and Technology of the Cellome, and chairs the Israel Cellome Network.
Prof. Deutsch is a leading expert on electromagnetics, as well as geometric and physical optics, and the areas of his expertise include: molecular physics, methods in spectroscopy, optical imaging, fluorescence, biophysics, medical physics, biotechnology, micro optics, microfluidics, micro fabrication, light microscopy, advanced image and signal analysis, microlithography, and miniaturization of laboratory techniques.
He is the recipient of numerous prestigious awards, and grants worth well over several million dollars from industrial, governmental and institutional sources, including the US Army. Professor Deutsch lectures worldwide, has published over 80 scientific articles, and holds 56 issued and pending patents in the US, Japan, Europe and Israel.
Research overview
Definition, research and performance of accurate fluorescence measurement and related derivatives (fluorescence polarization, life time, FRET, diffusion) in general, and in particular, those derived from individual cell.
Development of numerous nouveau biophysical parameters based on spatial, spectral and temporal analysis of label-free (transmitted light, auto fluorescence and electrochemical measurements) and fluorescence based images of single cells.
Design and production of numerous micro-structure platforms which enable performance of multi-parametric (high content) measurement, in an individual cell resolution, while in a population. Within these platforms, identity of the investigated cells, even those which are non adherent and non-tethered, is secured during long term kinetic measurement, while undergoing medium exchange, treatment, measurement and finally the analysis and biophysical interpretation of the results.
Development of a spheroid based assay approach (technology, methodology and readout). Design and fabrication of micro-structures for spheroid preparation, retention and screening, using optical imaging methods, as well as their adaptation for applications in biology research and medicine.