Microfluidics technology is being developed and incorporated into the Cell Retainers, to enable an effective use of extremely small sample volumes, precise cell treatment in the CR, and handling, separating and transferring single (rare) cells. In order to achieve these aims, the Cell Retainers have been modified to include internal fluid cross-vessels, reservoirs and input-output ports. This system is controlled by external micro-pumps, governed by automation software. The selection, segregation and re-location of specific cells is performed, within the internal microfluidic system, by laser tweezers and capillary micromanipulation.